Development of research hospitals:milestones and perspectives / 中华医院管理杂志

This paper explored the origin,concept,characteristics and evolution of the theories on research hospitals,along with a definition of the research concept.Furthermore,it reviewed the development history of research hospitals, role models and the achievements in building research hospitals.On such basis,the author predicted the future of such hospitals,and explored their leading roles in promoting the management innovation,mode innovation and technology innovation in modern hospitals,and its role in helping to solve main challenges in health care industry and achieve enlarged health.

Practice and review of building a research hospital at the General Hospital of Armed Police Force / 中华医院管理杂志

Based on a description of the positioning and characteristics of the hospital and its development roadblocks and mission,the authors studied practical experiences in building a research hospital.The hospital has achieved a leap-forward development thanks to its pursuit of quality as lifeline,innovative research and translation,enhancement of its role in rescue medicine innovation,and leveraging branding effect of rescue medicine.

Targeting gene therapy for bladder cancer using human UroplakinⅡ promoter / 中华泌尿外科杂志

Objective To investigate the feasibility of tissue-specific gene therapy for bladder cancer using human UroplakinⅡ(UPⅡ) promoter. Methods The recombinant adenoviruses,Ad-hUPⅡ-TNF carrying tumor necrosis factor (TNF-?) under control of the hUPⅡ,were generated.ELISA showed the production and secretion of TNF by bladder cancer cells infected with Ad-hUPⅡ-TNF.The level of TNF in urine was identified with ELISA. Results ELISA showed that production and secretion of TNF by bladder cancer cells infected with Ad-hUPⅡ-TNF was distinctly higher than by non-urothelium cells infected with Ad-hUPⅡ-TNF and MTT showed that proliferation of bladder cancer cells was obviously inhibited.Conditioned medium from bladder cancer cells apparently inhibited cells of L929 proliferation,compared with conditioned medium from non-bladder cells by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.Intravesical inoculation of Ad-hUPⅡ-TNF also caused decreased tumor growth in orthotopic human bladder cancer model.The sustained high level of TNF in urine could be identified with ELISA. Conclusions TNF driven by hUPⅡ promoter has effective active in the inhibition of bladder cancer growth both in vivo and in vitro.These will undoubtedly yield a new approach of therapy for bladder cancer.

Functional and pathological changes of lung tissues after bullet wound of dog's hind legs / 中国组织工程研究

BACKGROUND: Knowing the pathological changes of the lungs after the wallop from the bullet wound helps to improve the method or mean of dealing with the wound or to reduce the damage to lung functions after the wound.OBJECTIVE: To probe into the functional and pathological changes of the lung tissues after bullet wound.DESIGN: Open experimental study of the animals.SETTING: Department of the Integrated Traditional Chinese and Western Medicine, General Hospital of the Chinese People's Armed Police Forces.MATERIALS: The experiment was completed from June 2003 to December 2003 at the General Hospital of the Armed Police Forces. Six healthy grown-up cross-bred dogs, half male and half female, weighing ( 16.3 ± 0.58 ) kg, aged (8 - 12) months old, were provided by the Experimental Animal Center of the Military Academy of Sciences of Chinese PLA. Animal Center's license No. Was SCXK(army)2002-001. The animals were fed with water and food with no restrictions in an environment in which the temperature was 22 to 23 ℃ and the humidity was 74% - 80%.METHODS: Grown-up healthy domestic dogs were shot at the thick muscular part of their left hind legs with a size 81 automatic rifles, 7.62 mm in caliber and bullet of type-560. Caution was taken to avoid damage to the major vessels and the bone tissues. The shooting distance was 5 meters. Immediate hemostasis and bandaging were performed after shooting. And 6 hours later, pathological examination of the lungs was carTied out.MAIN OUTCOME MEASURES: Pathological changes of the lungs.RESULTS: After the bullet wound, the main pathological manifestations of the lungs were detelectasis of the pulmonary alveoli and the decrease of air volume complicated with inflammatory alveoli infiltration, lung edema, obscure structure of pulmonary alveoli, passive congestion of the small blood vessels, etc.CONCLUSION: The lung wound was obvious after bullet wound and its mechanism was associated with stress, inflammatory reaction of the adjacent tissues and far domino effect. Blood rheological changes after the wound were one of the most important factors to affect the microcirculation of the cerebral and lung tissues. It was found that clear blood rheological changes occurred at the earlier stage after the wound, and the chief manifestations included the increase of the whole blood viscosity and the index of the erythrocyte aggregation at the time of low sheering rate. The changes reached their peaks 6hours after the wound. On the one hand, because of the increase of whole blood viscosity and the index of erythrocyte aggregation, stasis of red blood cells might happen. And embolism of micro blood vessels in the brain and lungs would change the microcirculation of the brain and lungs. On the other hand, when serious injury of local tissues happens, the body's stress reaction would be strong and secretion and the release of stress hormones and certain active biological small molecular substances would increase, such as nitrogen monoxide(NO), tumor necrosis factor(TNF), endothelin(ET), etc. Their increase would stimulate the micro blood vessels of the brain and lungs and disturb their diastole and constriction functions. After the wound by high-speed projectile, blood flow volume in the animal's cerebral and lung tissues reduced sharply. The micrangium of the brain and lung dilated, and its diameter increased, which resulted in ischemia and hypoxia of the brain and lung tissues, and therefore edema of the brain and lung tissues and hypofunction of the lungs. Therefore, for the bullet wound of the limbs, in addition to dealing with local damage, the brain, the lungs and other important organs should be protected. This provides a theoretical basis for improving the brain and lung function after the bullet wound.

Study of brain function imaging induced by acupuncture at acupoint LI4(Hegu) / 中国康复理论与实践

@#ObjectiveTo investigate the time characteristics of brain function induced by acupuncture at acupoint of LI4(Hegu).MethodsThe data of functional magnetic resonance imaging(fMRI) induced by acupuncture at acupoint LI4(Hegu) was processed with modified temporal cluster analysis(MTCA) to obtain the time and trend of brain function.ResultsThe stimulation of acupuncture at acupoint LI4 induced the change of brain function,and time curve of brain functional during the acupuncture experiment was obtained.ConclusionThe effect of acupuncture at acupoint LI4(Hegu) on brain function has time characteristics.

INVESTIGATION OF THE INFLUENCE MENTAL BEHAVIOURS OF SOLDIERS DURING PERFORMING A TASK OF EMERGENCY / 解放军医学杂志

To probe influence of stress on the mental behaviours of soldiers. ①The mental behaviours during performing a task of emergency were investigated in 1033 soldieries. Of them, 200 performed the task of cracking smuggling activities, 338 the tasks of fighting a flood and sending relief to a disaster area, 187 the task of safeguarding the public order, and 98 task of pursuing and capturing escaped criminals, 210 the task of being on duty of internal conference of heads of state, and 200 as controls. ②The adult male rats were divited in to 4 groups and different stress impairment models were established. Spatial distinction ability was measured with jump platform test, avoidance action ability was determined with avoid lightless test. The results showed that the most servere stress was found in those who persued and captured the escaped criminals. Insomnia, amnesia,ballucination and loss of confidence were found in the remainders. It is suggestted that stress can lead to decrease in memory and response of human beings and rats.

Studies on physical stress of soldiers undergone 100 kilometers march in battle gear / 解放军医学杂志

Objective To study the physical stress reactions of soldiers undergone 100 kilometer march in battle gear,and explore the mechanism of biochemical changes in special military physical training.Methods Thirty four soldiers of armed-police force,averagely aged 18.6?1.6 years,169.3?4.2cm in height,weighted 65.4?4.5kg and with one-year of military physical training experience,were involved in present study.The soldiers were loaded about 25 kilogram of battle gear in a supervised 100 kilometer march in three days.The changes on biochemical index after the march were analyzed.Results After 100 kilometer march in battle gear,significant decline were found in the following biochemistry indexes in the soldiers involved: HB(P

Preliminary discussion of cooperation in international medical assistance / 中华医院管理杂志

The paper sums up experience in offering medical assistance to earthquake and tsunami victims in Algeria,Iran and Indonesia and discusses ways of strengthening cooperation between various rescuing teams and enhancing the efficiency and level of medical assistance,including exchanging medical assistance information in a timely and fast manner,jointly setting up emergency care stations in areas that could make use of the functions of the field hospitals,jointly conducting sanitation and anti-epidemic activities,resuming the treatment functions of clinics,grass-roots hospitals and large hospitals,and training medical workers.By strengthening cooperation between various international rescue teams,it is possible to bring into full play the advantages of each team,effectively use medical resources,and speed up the reconstruction of the medical systems in the disaster-stricken areas.